Potential therapeutic targets in multistep oncogenesis
Burns, P.A.; Balmain, A.
Seminars in Cancer Biology 3(6): 335-341
1992
ISSN/ISBN: 1044-579X PMID: 1286154 Document Number: 402484
There are three important considerations in the development of novel drug therapies: firstly, whether a suitable target can be accurately defined; secondly, does the target allow discrimination between normal cells and tumour cells; and thirdly, how easily could the tumour cells acquire resistance? This article will concentrate on two of the genetic alterations most commonly associated with multistep tumourigenesis, and discuss their potential as therapeutic targets with respect to the considerations above.