Inhibition of the activation of Hageman factor (factor XII) by aprotinin (Trasylol)
Laurel, M.T.; Ratnoff, O.D.; Everson, B.
Journal of Laboratory and Clinical Medicine 119(5): 580-585
1992
ISSN/ISBN: 0022-2143 PMID: 1374787 Document Number: 402466
Aprotinin (Trasylol; Bayer AG, Leverkusen, Germany), a protease inhibitor resembling or identical with Kunitz' pancreatic trypsin inhibitor, is said to have anticoagulant properties, but these are not clearly defined. The present study provides evidence that one action of aprotinin is inhibition of the activation of Hageman factor (factor XII).
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