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Activation of the contact system in ascites from patients with gastrointestinal cancer

Buø, L.; Karlsrud, T.S.; Johansen, H.T.; Aasen, A.O.

Agents and Actions. Supplements 38: 237-248

1992

ISSN/ISBN: 0379-0363
PMID: 1281373
Document Number: 402092
Our observations indicates that the plasma contact system is activated in ascites from patients with gastrointestinal cancer: Factor XII is activated, plasma kallikrein is present in complex with the protease inhibitor alpha 2-macroglobulin, and the plasma kallikrein substrate high molecular weight kininogen, is highly degraded. Contact activation seems to take place in spite of a high level of inhibition. Activation of the contact system generates mediators, which may play a role in the accumulation of ascites.

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