The microbiology of irradiation sterilization
Halls, N.
Medical Device Technology 3(6): 37-45
1992
ISSN/ISBN: 1048-6690 PMID: 10147984 Document Number: 401641
In his discussion of the microbiological aspects of irradiation sterilization, the author examines the effects of irradiation on microbial populations and describes how sterility is assured and sterilization is achieved as well as the factors affecting lethality. Microbial response to radiation depends not on the dose rate but is influenced by the innate characteristics of the microorganisms and the physical or chemical conditions or agents existing within the cells or their immediate environment. Many external factors, including the effects of oxygen, water, other chemical agents, and temperature can protect or sensitize microorganisms from or to lethal radiation-induced damage. The microbiology of irradiation sterilization is an extremely wellresearched area of science. Where the determinants of sterility by irradiation, namely the selection of doses appropriate to internationally recognized SALs, and particular process control systems are based on this research, there can be a high level of confidence in achieving product sterility.