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The role of endotoxin in the pathogenesis of experimental multiple system organ failure: a preliminary report

Yao, Y.; Tian, H.; Sheng, Z.; Wang, Y.P.; Shi, Z.; Lan, F.

Chinese Medical Sciences Journal 7(3): 161-165

1992

ISSN/ISBN: 1001-9294
PMID: 1286184
Document Number: 401528
In this study, an animal model of multiple system organ failure (MSOF) in rabbits, engendered by feeding E. coli prior to severe hemorrhagic shock, was used for the purpose of investigating 1) the relationship between lipopolysaccharide (LPS) and MSOF, and 2) the effectiveness of Re-LPS antiserum in preventing MSOF. The results showed that endotoxemia occurred very early, and its degree correlated well with that of organ dysfunction. Re-LPS antiserum administration abated the toxic effects and lowered the incidence of MSOF. These results suggest that sequential analysis of circulating LPS levels may be useful for the early diagnosis of MSOF, and that gut-derived endotoxin might play an important role in the pathogenesis of experimental MSOF.

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Pavlovs'kyĭ, M.P.; Oborin, O.M.; Ivankiv, T.M. 1997: The role of the intestines in the pathogenesis of the multiple organ failure syndrome Likars'ka Sprava 4: 21-26
Endo, S.; Inada, K.; Takakuwa, T.; Nakae, H.; Kikuchi, M.; Kuwata, Y.; Yoshida, M. 1994: Levels of soluble CD14 in patients with septic multiple organ failure (MOF): preliminary report Nihon Geka Gakkai Zasshi 95(2): 129
Giomarelli, P.; Chiara, O.; Borrelli, E. 1992: Lipoperoxidation in multiple organ failure: experimental model Minerva Anestesiologica 58(10): 1037-1040
Chi, M.; Qi, L.; Cai, A.; Zhang, Y.; Li, F.; Jia, X. 2014: Heart failure, metabolic acidosis, and postoperative multiple organ failure after anesthesia for cesarean section in a patient with Takayasu arteritis: a case report Clinical and Experimental Obstetrics and Gynecology 41(5): 583-586
Doran, J.E.; Lundsgaard-Hansen, P. 1988: Role of the reticuloendothelial system in the pathogenesis of organ damage British Journal of Hospital Medicine 39(3): 221-225
Zapata-Sirvent, R.L.; Hansbrough, J.F. 1992: Bacterial translocation. its role in the etiology of sepsis and multiple organ failure G.E.N 46(2): 137-151
Sheng, Z.Y.; Dong, Y.L.; Wang, X.H. 1991: Bacterial translocation and multiple system organ failure in bowel ischemia and reperfusion Chinese Medical Journal 104(11): 897-903
Landercasper, J.; Miller, C.H.; Boyer, D.D. 1987: Toxic shock syndrome and multiple-system organ failure after breast biopsy Surgery 102(1): 96-98
León-Regidor, M.A.; García-Cors, M.; Ayuso-Gatell, A.; Mestre-Saura, J.; Díaz-Boladeras, R.M.; Nolla-Salas, M. 1993: Cerebral malaria and multiple organ failure. A case report Revista Clinica Espanola 192(7): 331-333
Tran, D.D.; Cuesta, M.A.; van Leeuwen, P.A.; Nauta, J.J.; Wesdorp, R.I. 1993: Risk factors for multiple organ system failure and death in critically injured patients Surgery 114(1): 21-30
Riabov, G.A.; Azisov, I.M. 2001: Role of nitric oxide as a regulator of cell processes in the formation of multiple organ failure Anesteziologiia i Reanimatologiia 1: 8-13
Possamai, C.; Corbanese, U.; Possamai, G.; Casagrande, L.; Farinea, C. 1997: Multiple organ failure due to Clostridium difficile sepsis. A case report Minerva Anestesiologica 63(6): 205-207
Holzheimer, R.G.; Molloy, R.; Mendez, M.V.; O'Riordain, D.; Curley, P.; Nestor, M.; Collins, K.; Saproschetz, I.; Mannick, J.A.; Rodrick, M.L. 1995: Multiple system organ failure may be influenced by macrophage hypoactivation as well as hyperactivation--importance of the double challenge European Journal of Surgery 161(11): 795-803
Genovese, A.; Cacciapuoti, A.A.; Polverino, W.; Chiariello, M.; De Alfieri, W.; Condorelli, M. 1979: The role of calcium in the pathogenesis of experimental infarct induced with isoproterenol in the rat. Preliminary findings. i Minerva Cardioangiologica 27(12): 783-788
Yang, Z. 1991: An experimental study on the role of fluid replacement in the prevention of organ failure after burn injury Zhonghua Yi Xue Za Zhi 71(4): 190-4 14
Pokrovskiĭ, V.I.; Radzivil, G.G.; Beloborodov, V.B.; Broniakin, I.V.; Roslyĭ, I.M. 1986: Role of hemosorption in the therapy of infectious toxic shock and the multiple-organ failure syndrome in a fulminating form of meningococcemia Terapevticheskii Arkhiv 58(9): 117-122
Panchenkov, R.T.; Iarema, I.V. 1979: Role of the lymphatic system in the pathogenesis of acute hepatic failure Vestnik Akademii Meditsinskikh Nauk SSSR 9: 69-75
Mitkov, D. 1993: The role of the octanoic fatty acid in the pathogenesis of the metabolic alkalosis in experimental liver failure Folia Medica 35(1-2): 23-27
Fukuda, T.; Sumi, T.; Nobeyama, H.; Yoshida, H.; Matsumoto, Y.; Yasui, T.; Honda, K.-I.; Ishiko, O. 2009: Multiple organ failure of tumor-bearing rabbits in cancer cachexia is caused by apoptosis of normal organ cells International Journal of Oncology 34(1): 61-67
Vignali, G.; Rogato, G.; Mondello, V.; Vignale, L.; Guadagnucci, A.; Vignali, F.; Tulli, G. 1990: ARDS in MOFS (multiple organ failure syndrome). How to direct the therapy? A case report of MOFS in AIDS Minerva Anestesiologica 56(1-2): 1-5