Lymphoma induction by human B cells in scid mice
Amadori, A.; Veronese, M.L.; Mazza, M.R.; Zamarchi, R.; Mion, M.; D'Andrea, E.; Menin, C.; Del Mistro, A.; Leszl, A.; Calderazzo, F.
Leukemia 6(Suppl 3): 23s-25s
1992
ISSN/ISBN: 0887-6924 PMID: 1318472 Document Number: 401070
Lymphoma development was studied in scid mice injected i.p. with PBMC from EBV-positive donors. Most injected mice developed oligo/monoclonal B-cell tumors within 4 months after the inoculation; EBV genome was found in tumor cells. Removal of T lymphocytes from the injected cell populations prevented lymphoma development in all mice, suggesting that T-cell-derived factors are involved in the expansion of the latently EBV-infected B-cell population within the immunodeficient host.
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