Variability of serum levels for three oral 8-methoxypsoralen brands
Walther, T.; Quednow, B.; Haustein, U.F.; Meyer, F.P.
Photodermatology Photoimmunology and Photomedicine 9(1): 1-3
1992
ISSN/ISBN: 0905-4383 PMID: 1390116 Document Number: 400326
We conducted a pilot study to investigate the serum level patterns of 3 commerical and internationally introduced 8-methoxypsoralen (8-MOP) preparations in 9 patients for their bioequivalence and registered the interindividual variability of serum levels over 8 h after intake of 30 mg 8-MOP equivalent doses. On average, the highest serum levels (C-max 120.1, range 235-61 ng cntdot ml-1) were reached as early as 0.5-1 after ingestion of Geroxalen soft gelatin capsules, whereas lower serum levels were seen after intake of the Oxsoralen hard gelatin capsules (C-max 82.3, range 154-47 ng cntdot ml-1) and the Mopsoralen tablets (C-max 81.3, range 172-26 ng cntdot ml-1). The importance of 8-MOP serum level determination for better and efficient PUVA therapy is discussed.