Serum antibody levels after immunization with trivalent oral poliovirus vaccine
Pollak, O.; Power, D.J.; Bundred, P.; Joosting, A.C.
South African Medical Journal 57(6): 191-193
1980
ISSN/ISBN: 0256-9574 PMID: 7361209 Document Number: 163093
The antibody titres to the polioviruses after three doses of trivalent oral poliovirus vaccine were assessed in 77 Coloured children aged 3-9 months. Neutralizing antibody titres of 1 in 10 or greater to all three types were found in 59 (77%) of all children. The remaining 18 children lacked demonstrable antibody to one or more of the polioviruses. Antibody to types 1 and 3 was most commonly lacking. The possible reasons for the failure of vaccination in so many children is discussed. Studies of the effect of further doses of vaccine on serum antibody levels are recommended.