Myxoid change in malignant lymphoma. Pathogenetic considerations
Fung, D.T.; Chan, J.K.; Tse, C.C.; Sze, W.M.
Archives of Pathology and Laboratory Medicine 116(1): 103-105
1992
ISSN/ISBN: 0003-9985 PMID: 1370876 Document Number: 399831
Myxoid change is a rare phenomenon in malignant lymphoma, and its pathogenesis is not well understood. We present in a case of large B-cell lymphoma of the small bowel in which myxoid change is confined to one of the regional lymph nodes involved by lymphoma. An increase of vimentin-positive mesenchymal cells in the myxoid zones compared with the nonmyxoid areas within the lymph node and a complete lack of myxoid change in the tumour occurring in other sites of this case suggest that the myxoid stroma results from some local factors (most probably tissue edema) stimulating proliferation of fibroblasts/myofibroblasts.