Celiac sprue in Down's syndrome: considerations on a pathogenetic link
Nowak, T.V.; Ghishan, F.K.; Schulze-Delrieu, K.
American Journal of Gastroenterology 78(5): 280-283
1983
ISSN/ISBN: 0002-9270 PMID: 6221657 Document Number: 203823
The association of celiac disease with Down's syndrome is described in two patients who presented with features of the malabsorption syndrome. The diagnosis was readily made by peroral jejunal mucosal biopsy. Both patients responded clinically to dietary gluten withdrawal and one patient demonstrated a recrudescence of symptoms and reappearance of jejunal mucosal atrophy upon rechallenge with dietary gluten. Genetic considerations in the etiology of both disorders are discussed.