Effect of cimetidine on isolated rat myocardial reperfusion injury
Wu, S.; Hu, H.C.; Xu, X.Z.
Zhongguo Yao Li Xue Bao 13(1): 13-16
1992
ISSN/ISBN: 0253-9756 PMID: 1605027 Document Number: 399288
The effects of cimetidine (Cim) on ventricular fibrillation threshold (VFT), diastolic excitation threshold (DET), effective refractory period (ERP), and vulnerable period (VP), were determined in both stable perfusion and postischemic reperfusion rat hearts. The results showed that reperfusion after 15 min global myocardial ischemia caused a significant decrease VFT and ERP, and an increase in VP and DET. Cim 1 mmol .cntdot. L-1 prevented the lowering in VFT, shortening in ERP, and lengthening in VP from the postischemic reperfusion. Cim 0.1 mmol .cntdot. L-1 attenuated the exacerbation of VFT and VP. Cim 0.01 mmol .cntdot. L-1 did not exert any noticeable influence on the electrophysiological parameters. It was shown that Cim 1 mmol .cntdot. L-1 protected myocardium against the aggravation of electrophysiological characteristics induced by postischemic reperfusion.