Dissolution and polymorphism of metolazone
Burger, A.
Arzneimittel-Forschung 25(1): 24-27
1975
ISSN/ISBN: 0004-4172 PMID: 1173767 Document Number: 3992
The solubility and dissolution rate of five different solid forms of 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-o-tolyl-6-quinazoline-sulfonamide (metolazone) in n-butanol, water and 0.01 n HCl are investigated and thermodynamic values have been computed. The amorphous metolazone dissolves about 8 times faster than the stable modification I (mp. 267-270 degrees C) in 0.01 n HCl at 37 degrees C.
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