A clinico-experimental study of the tocolytic properties of salbupart in treating threatened abortion
Murashko, L.E.; Sheveleva, G.A.; Strel'chenko, N.V.; Filimonov, V.G.; Sidel'nikova, V.M.
Akusherstvo i Ginekologiia 1992(8-12): 24-27
1992
ISSN/ISBN: 0300-9092 PMID: 1292355 Document Number: 398227
Clinical and experimental studies have revealed that salbupart, a beta-mimetic agent, administered in a dose of 0.14 mg/kg (the maximal therapeutic dose) markedly inhibited the spontaneous and oxytocin-induced uterine contractility, caused no embryotoxic or teratogenic effects, and did not influence fetal growth and development. The efficacy of salbupart tocolytic therapy was estimated as 75%. Blood plasma cAMP levels normalized in the pregnant women over the course of therapy. Clinical and experimental results recommend salbupart for pregnancy protecting therapy in cases with threatened spontaneous abortions.