Is localization of B-cells in the acini a normal condition or the sign of compensatory process in insulin-dependent diabetes mellitus?
Severgina, E.S.; Diuzheva, T.G.; Razgulina, L.E.; Stakheev, I.B.
Arkhiv Patologii 54(12): 18-23
1992
ISSN/ISBN: 0004-1955 PMID: 1296565 Document Number: 397785
45 pancreatic biopsies from patients with insulin-dependent diabetes mellitus (IDDM), obtained in the process of surgical treatment were studied. A different degree of the Langerhans islands and morphological changes in B-cells was noted. The presence of endocrine-like cells in the acini and among the cells of the interacinar duct is of great interest. The granules of these cells were insulin-positive when studied immunohistochemically, thus permitting one to consider them as B-cells. Further study of these cells will allow to deepen the knowledge about the mechanism of IDDM development and to improve the methods of treatment.