Minimal residual disease in leukemia: state of the art 1991
Hagenbeek, A.
Leukemia 6(Suppl 2): 12-16
1992
ISSN/ISBN: 0887-6924 PMID: 1578911 Document Number: 397404
Recent achievements in decreasing the detection level of "minimal residual disease" in leukemia are summarized both in a relevant rat model for acute myelocytic leukemia (BNML) and in the human leukemias. Detection levels as low as 1 leukemic cell per 10(8)-10(9) and 10(5)-10(6) normal bone marrow cells have become realistic in the animal model and in human leukemia, respectively. The implications of these new tools for detecting hidden leukemic cells are discussed.
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