Lack of effect of diacetyl-splenopentin (Berlopentin) on the pharmacokinetics of caffeine
Simon, H.U.; Kraul, H.; Schäfer, R.; Kilian, U.; Hoffmann, A.
Die Pharmazie 47(1): 49-50
1992
ISSN/ISBN: 0031-7144 PMID: 1608985 Document Number: 397240
The influence of Berlopentin on caffeine clearance was measured after a 6 week i.v. treatment or a 4 week s.c. administration within a phase I trial. It was demonstrated that therapy with Berlopentin did not affect significantly caffeine elimination. Thus, clearance of drugs which are biotransformed by hepatic microsomal oxidation are unlikely to be affected by the coadministration of Berlopentin.