Recent advances in the etiopathology of chronic B-lymphocytic leukemia
Rupniewska, Z.M.
Postepy Higieny i Medycyny Doswiadczalnej 46(4): 381-402
1992
ISSN/ISBN: 0032-5449 PMID: 1363442 Document Number: 397140
Considerations to multistep development of B-lymphocytic chronic leukaemia are presented under the following aspects: experimental in vitro cultures of bone marrows B lymphocyte precursors, polyclonal nature of proliferating B lymphocytes in the early stage of CLL, especially in the autoimmune status, the role of viruses, the effect of nonrandom chromosome abnormalities and associated alterations in gene functions, clonal evolution during terminal stages of CLL.