Treatment of nocturnal leg cramps. A crossover trial of quinine vs vitamin E
Connolly, P.S.; Shirley, E.A.; Wasson, J.H.; Nierenberg, D.W.
Archives of Internal Medicine 152(9): 1877-1880
1992
ISSN/ISBN: 0003-9926 PMID: 1520054 Document Number: 396711
Objective: This study compared the efficacy and safety of quinine sulfate, vitamin E, and placebo in the treatment of nocturnal leg cramps. Design: A random-order, double-blind, placebo-controlled crossover trial was performed. Setting: The study was conducted at the Veterans Affairs Medical Center, White River Junction, Vt. Participants: Twenty-seven male veterans, aged 38 to 73 years, who experienced at least six leg cramps per month were recruited through the general medicine walk-in clinic or were referred from other clinics. Fifty-five subjects were contacted, 30 were enrolled consecutively, and 27 completed the study. Intervention: Subjects received, in random order, quinine sulfate (200 mg at supper and 300 mg at bedtime), vitamin E (800 U at bedtime), or placebo for 4-week periods. These periods were separated by 4-week washout intervals. Outcome Measures: Patients reported cramp frequency, severity, and sleep disturbance caused by cramps. Results: Compared with treatment with placebo, quinine reduced the frequency of cramps and sleep disturbance, but not the average cramp severity. Thirteen of 27 patients had at least a 50% reduction in the number of cramps while receiving quinine; the response was usually seen within 3 days. There was evidence of a mild increase in side effects while subjects received quinine. Vitamin E was not effective in reducing leg cramp frequency, severity, or sleep disturbance. Conclusions: Quinine sulfate, but not vitamin E, is superior to placebo in the treatment of nocturnal leg cramps.