Double-blind crossover clinical trial of oxyfedrine and propranolol in angina pectoris
Sagar, S.; Pandhi, P.; Anand, I.S.; Sharma, P.L.; Wahi, P.L.
International Journal of Clinical Pharmacology Therapy and Toxicology 23(4): 186-189
1985
ISSN/ISBN: 0174-4879 PMID: 3888857 Document Number: 256652
The comparative efficacy and safety of oxyfedrine and propranolol in the management of angina pectoris was evaluated in a double-blind randomized cross-over study. Out of 21 patients registered, 14 completed the study. Three patients dropped out due to poor response and 4 were lost to follow up. Both the drugs i.e. oxyfedrine (8-24 mg three times a day) and propranolol (40-80 mg three times a day) produced a significant reduction in the incidence of anginal attacks and the consumption of nitroglycerine tablets. Propranolol produced a better response than oxyfedrine although the difference was not significant. This may be due to the small sample size. No change in heart rate and rate-pressure product was observed with oxyfedrine, in contrast to that seen with propranolol. The beneficial effect of treatment on exercise tolerance and ST-segment depression was more marked with propranolol. No significant change in laboratory parameters was observed with either drug.