Cytotoxicity test on medical drugs--chromosome aberration tests with Chinese hamster cells in vitro
Ishidate, M.; Hayashi, M.; Sawada, M.; Matsuoka, A.; Yoshikawa, K.; Ono, M.; Nakadate, M.
Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 1978(96): 55-61
1978
ISSN/ISBN: 0077-4715 PMID: 750044 Document Number: 3967
Chromosome aberration tests in vitro were carried out on medical drugs and their related compounds using Chinese hamster fibroblast cells in culture. Each drug of different doses was exposed directly to the cells and chromosome preparations were made 24 h and 48 h after treatment. Forty two out of 71 were negative even at the dose when cell proliferation was remarkably reduced. Remaining 29 compounds produced more or less chromosome aberrations, in which compounds also positive in mutation assays with bacteria were included. Several compounds were pointed out as mitotic poisons, which produced polyploid cells rather than cells with morphological changes in chromosomes.
Document emailed within 1 workday
