Efficacy of the combination of nicardipine-enalapril and atenolol in severe hypertension secondary to chronic renal disease
Melina, D.; Guerrera, G.; Santoliquido, A.; Guerrera, C.; Musumeci, V.; Nicolò, G.; Cataldo, R.
Annales de Cardiologie et d'Angeiologie 41(6): 351-353
1992
ISSN/ISBN: 0003-3928 PMID: 1444161 Document Number: 396531
The antihypertensive efficacy of combination therapy with N-E-A was evaluated during 6 months in 15 patients with hypertension associated with mild to moderate kidney failure. After 6 months a significant reduction of SBP and DBP (p < 0.001), with improvement of creatinine clearance and with no adverse effects on ECG, heart rate and routine laboratory tests test, was observed in 3 patients treated with N 20 mg x 2/d + E 10 mg/d + A 50 mg/d and in 8 patients treated with N 20 mg x 3 + E 10 mg x 2, + A 50 mg x 2. Four patients did not respond to this therapy.