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Effects of silybin on acute myocardial infarction and reperfusion injury in anesthetized rats

Chen, H.; Su, D.F.; Zhang, T.H.; Ding, H.J.; Yang, Y.C.; Chen, S.C.

Zhongguo Yao Li Xue Bao 13(1): 69-71

1992

ISSN/ISBN: 0253-9756
PMID: 1605039
Document Number: 395870
The effects of silybin (Sil) on myocardial infarction size and ischemia- and reperfusion-induced arrhythmias were studied in anesthetized open chest Sprague-Dawley rats. It was found that pretreatment with Sil 20, 50, and 80 mg .cntdot. kg-1 iv reduced significantly infarct size by 34.7%, 35.0%, and 50.6% respectively at 4 h after ligation. Sil prevented ischemic arrhythmia only at the dose of 80 mg .cntdot. kg-1. In reperfusion experiment, pretreatment with Sil 20 mg .cntdot. kg-1 decreased significantly reperfusion-induced arrhythmia.

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