Inhibition of photosensitization of morin on DNA synthesis of ascites hepatoma cells
Zhou, X.F.; Zheng, R.L.; Huang, M.
Zhongguo Yao Li Xue Bao 13(2): 186-188
1992
ISSN/ISBN: 0253-9756 PMID: 1598839 Document Number: 395159
Morin (0.012, 0.012, 1.2, 12.0 .mu.g .cntdot. ml-1) significantly inhibited DNA synthesis of ascitic hepatoma (AH) cells. The inhibition of DNA synthesis and cell mortality was dependent on its concentrations as well as the illumination time. Photosensitization of morin was not due to 1O2, and O2.-, but closely related to OH. and H2O2. The mechanism of the inhibition may be attributed to the damage of DNA replication template.