Top Abstract Purchase Related
Home
>
Node
>
Subnode

Inhibition of phospholipid reacylation in oxidative damage of tumor cells

Kondakova, I.V.; Borunov, E.V.; Bondarenko, E.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 113(5): 522-524

1992

ISSN/ISBN: 0365-9615
PMID: 1421279
Document Number: 395110
In this study we examined the effect of oxidative stress on phospholipid reacylation and (1-14C)arachidonic acid uptake by murine mastocytoma P815 cells. Tert-butyl hydroperoxide inhibited arachidonic acid uptake by P815 cells and incorporation of fatty acid into main cellular phospholipids. Specific activity of control phosphatidylcholine was about 15-fold higher than that of phosphatidylcholine from tert-butyl hydroperoxide-treated cells. For phosphatidylethanolamine and phosphatidylinositol this inhibition was about 7-fold and 12-fold, respectively. Thus, oxidative stress causes the drastic changes in the process of phospholipid repair, which may significantly disorder membrane stability.

Document emailed within 1 workday
Secure & encrypted payments

Hänsch, G.M.; Gemsa, D.; Resch, K. 1985: Induction of prostanoid synthesis in human platelets by the late complement components C5b-9 and channel forming antibiotic nystatin: inhibition of the reacylation of liberated arachidonic acid Journal of Immunology 135(2): 1320-1324
David, O.; Sacchetti, L.; Vota, M.G.; Comino, L.; Perugini, L.; Pescarmona, G.P. 1990: Pyrimidine 5'-nucleotidase and oxidative damage in red blood cells transfused to beta-thalassemic children Haematologica 75(4): 313-318
Franks, S.E.; Kuesel, A.C.; Lutz, N.W.; Hull, W.E. 1996: 31P MRS of human tumor cells: effects of culture media and conditions on phospholipid metabolite concentrations Anticancer Research 16(3b): 1365-1374
Kolachana, P.; Subrahmanyam, V.V.; Meyer, K.B.; Zhang, L.; Smith, M.T. 1993: Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo Cancer Research 53(5): 1023-1026
Shi, L-Qin.; Zheng, R-Liang. 2006: DNA damage and oxidative stress induced by Helicobacter pylori in gastric epithelial cells: protection by vitamin C and sodium selenite Die Pharmazie 61(7): 631-637
Ávalos, A.; Haza, A.I.; Morales, P. 2015: Manufactured silver nanoparticles of different sizes induced DNA strand breaks and oxidative DNA damage in hepatoma and leukaemia cells and in dermal and pulmonary fibroblasts Folia Biologica 61(1): 33-42
Saha, B.; Subramanian, M.; Gupta, P.; Patro, B.S.; Ray, J.; Bandyopadhyay, S.K.; Chattopadhyay, S. 2016: Trans-4,4'-Dihydroxystilbene (DHS) protects PC12 cells from oxidative damage but induces reactive oxygen species-mediated apoptosis in SHSY-5Y cell line Indian Journal of Experimental Biology 54(11): 719-728
Zhong, G.G.; Jiang, Y.; Li, Z.B.; Zhang, B.G.; Zhang, W.J.; Yue, G. 1990: Protective action of selenium and manganese on xanthine and xanthine oxidase induced oxidative damage to cultured heart cells Chinese Medical Journal 103(9): 735-742
de Tinguy-Moreaud, E.; Pourquier, P.; Montaudon, D.; Robert, J. 1994: Relationships between DNA damage and growth inhibition induced by topoisomerase II-interfering drugs in doxorubicin-sensitive and -resistant rat glioblastoma cells Anticancer Research 14(1a): 99-103
Drapier, J.C.; Hibbs, J.B. 1988: Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells Journal of Immunology 140(8): 2829-2838
Reidy, G.F.; Mehta, I.; Murray, M. 1989: Inhibition of oxidative drug metabolism by orphenadrine: in vitro and in vivo evidence for isozyme-specific complexation of cytochrome P-450 and inhibition kinetics Molecular Pharmacology 35(5): 736-743
Erikson, J.M.; Tweedie, D.J.; Ducore, J.M.; Prough, R.A. 1989: Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells Cancer Research 49(1): 127-133
Hahn, G.M.; Rockwell, S.; Kallman, R.F.; Gordon, L.F.; Frindel, E. 1974: Repair of potentially lethal damage in vivo in solid tumor cells after x-irradiation Cancer Research 34(2): 351-354
Lisitsa, A.V.; Soodaeva, S.K.; Klimanov, I.A.; Aver'ianov, A.V. 2014: Oxidative stress in pathogenesis of bronchial asthma: a method of correction by inhalation of phospholipid nanoparticles Klinicheskaia Meditsina 92(10): 45-52
Harm, H. 1978: Damage and repair in mammalian cells after exposure to non-ionizing radiations. I. Ultraviolet and visible light irradiation of cells of the rat kangaroo (Potorous tridactylus) and determination of photorepairable damage in vitro Mutation Research 50(3): 353-366
Cerutti, P.A.; Sessions, F.; Hariharan, P.V.; Lusby, A. 1978: Repair of DNA damage induced by benzo(a)pyrene diol-epoxides i and Ii in human alveolar tumor cells Cancer Research 38(7): 2118-2124
Walos, S.; Szary, J.; Szala, S. 1999: Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells Acta Biochimica Polonica 46(4): 967-970
Hanna, N. 1982: Inhibition of experimental tumor metastasis by selective activation of natural killer cells Cancer Research 42(4): 1337-1342
Cory, J.G.; Parker, S.H.; Fox, C.S. 1978: Inhibition of RNA synthesis in Ehrlich tumor cells by the dialdehyde derivative of inosine (NSC 118994) Cancer Research 38(3): 815-822
Umeda, M.; Noda, K.; Ono, T. 1980: Inhibition of metabolic cooperation in Chinese hamster cells by various chemical including tumor promoters Gan 71(5): 614-620