The effects of local hyperthermia on the morphology of the small bowel
Tóth, T.; Fenyvesi, A.; Klemm, I.
Acta Physiologica Hungarica 80(1-4): 293-301
1992
ISSN/ISBN: 0231-424X PMID: 1345199 Document Number: 394664
Intestinal lesions were produced experimentally by beating the eventrated loop of the small intestine of Wistar rats in 44 degree C C 0.9% saline 20 minutes. Luminal haemorrhage and elevation of the potassium concentration in the wash-cut fluid were registered from the fifth minute of the experiment. In the sediment of the wash-out fluid erythrocytes, degenerated and necrotic epithelia) cell clusters were found. Histologically the mildest lesions were subnuclear vacuolization of the epithelial cells and stromal oedema of the villi. In the medium-degree lesion subepithelial cleft formation, desquamation of the epithelial cells and denudation of the villi occurred. The fully developed lesion was characterized by the destruction of the villi intestinales and haemorrhage. This lesion produced by local heating differs from the intestinal lesions of the rats exposed to high environmental temperature basically in the haemorrhagical nature of the former lesion.