Effects of propafenone on pacing-induced ventricular fibrillation and intracellular calcium in rat hearts
Stefenelli, T.; Wu, S.T.; Parmley, W.W.; Wikman-Coffelt, J.
European Heart Journal 13(11): 1556-1561
1992
ISSN/ISBN: 0195-668X PMID: 1334467 Document Number: 393825
Propafenone is an antiarrhythmic agent with fast sodium channel, calcium channel, and beta-adrenergic receptor blocking properties. The effects of propafenone on arrhythmias, free intracellular calcium and left ventricular performance were studied using perfused rat hearts during (i) pacing-induced ventricular fibrillation and (ii) infusion with 2.65 times 10-6 M, 5.3 times 10-6 M and 7.9 times 10-6 M propafenone hydrochloride (corresponding to approximately 1, 2 and 3 mg kg-1 body weight). A bolus of 1 mg kg-1 propafenone during ventricular fibrillation resulted in a decrease in intracellular calcium, with subsequent conversion to sinus rhythm. In perfused hearts with sinus rhythm propafenone produced a dose-dependent decrease in heart rate and myocardial oxygen consumption together with a rise in left ventricular diastolic pressure, and diastolic (Ca-2+)-i, indicative of depression of left ventricular function. We conclude that a bolus of propafenone during ventricular fibrillation leads to a decrease in (Ca-2+)-i preceding conversion to sinus rhythm. In rat hearts with sinus rhythm the depressive effects of propafenone on (Ca-2+)-i are dose dependent.