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Expression of cytochrome P-450 genes

Lutz, W.

Postepy Higieny i Medycyny Doswiadczalnej 46(1): 1-20

1992

ISSN/ISBN: 0032-5449
PMID: 1641372
Document Number: 393130
Cytochromes P-450 are important in the oxidative metabolism of many endogenous substrates, as well as innumerable drugs, chemical carcinogens, and environmental pollutants. Biochemical analyses of cytochrome P-450 have revealed multiple isoenzymes. Information for synthesis of these isoenzymes is contained in different genes. Based on the degree of relatedness in DNA sequence, the genes for cytochrome P-450 have been classified into different families, constituting cytochrome P-450 multigene superfamily. Particular chemicals induce expression of one or more genes belonging to definite cytochrome P-450 family. Expression of these genes may have served as a mechanism by which the cell respond to specific chemical signals (xenobiotic or hormonal).

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