Recognition and structural perturbation of GC box DNA by Sp1 zinc finger
Kuwahara, J.; Futamura, M.; Yonezawa, A.; Sugiura, Y.
Nucleic Acids Symposium Series 27: 175-176
1992
ISSN/ISBN: 0261-3166 PMID: 1289808 Document Number: 392903
Interaction of Sp1 with GC box DNA was investigated by several footprinting experiments. Methylation of four guanine bases is strongly protected by Sp1 binding, while one guanine base in GC box is extremely hypermethylated. Sp1 binding also induces new cleavage at 5'-GA-3' site within GC box by bleomycin-iron complex.
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