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Metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 in rat liver

Lim, H.B.; Sohn, H.O.; Lee, Y.G.; Lee, D.W.

Biochemistry International 28(3): 543-550

1992

ISSN/ISBN: 0158-5231
PMID: 1482393
Document Number: 392885
The metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 system was studied with two different inductions. At least 5 different metabolites with higher polarity were produced from 16 alpha-hydroxytestosterone. MT-B, one of their products, appeared to be specifically increased by 3-methylcholanthrene- and phenobarbital-inducible P-450, respectively. This suggests that monohydroxylated testosterones are further metabolized by the P-450 system and that the reactions are isozyme specific. This can contribute at least in part to the diversity of steroid metabolism by P-450.

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