Effect of changes in erythrocyte lipid spectrum on erythrocyte functional parameters in patients with diabetes mellitus
Ishankhodzhaev, T.M.; Bornikov, V.T.; Saatov, T.S.; Zaĭnutdinov, B.R.
Problemy Endokrinologii 38(5): 53-55
1992
ISSN/ISBN: 0375-9660 PMID: 1480594 Document Number: 392403
Studies of the red cell lipid spectrum in diabetics and of the effects of bioactive substances and reconstruction of the red cell membrane lipid component on these cells aggregation have shown increased levels of lysophosphatidylcholine, cholesterol, cholesterol to phospholipid ratio, and saturated fatty acids in the presence of phosphatidylcholine reduction. Fluctuations in the levels of lipids of other classes were also revealed. Studies of red cell aggregation have revealed that incubation of donors' and diabetics' red cells with hormones did not lead to essential changes in the aggregation induced by alcian blue. Addition of an aliquot of plasma enriched for platelets, glycolipids and alpha-tocopherol resulted in a marked reduction of the aggregation degree and size of the aggregate. Phosphatidylcholine, phosphatidylinositol, and cholesterol-enriched liposome reconstruction of the red cell lipid composition also resulted in reduction of the aggregation degree and of the size of the red cell aggregate. This has brought the authors to a conclusion on a close relationship between the red cell lipid composition and the aggregation capacity in diabetics and on the possibility of regulating the red cell aggregation activity with bioactive substances.