HMB-45 reactivity in adrenal pheochromocytomas
Unger, P.D.; Hoffman, K.; Thung, S.N.; Pertsemlides, D.; Wolfe, D.; Kaneko, M.
Archives of Pathology and Laboratory Medicine 116(2): 151-153
1992
ISSN/ISBN: 0003-9985 PMID: 1733408 Document Number: 391637
Melanoma-specific antibody (HMB-45) is highly specific for junctional nevi, malignant melanomas, and related lesions. Rarely have other benign or neoplastic tissues demonstrated positivity with the monoclonal antibody following purification. In the present study, four of 12 pheochromocytomas contained chief cells that reacted with HMB-45. We discuss the clinical and pathologic implications of this finding.