Bromocriptine for macroprolactinomas. Discussion of 3 cases treated successfully
Sapunar, J.; López, J.M.; Huete, I.; Tagle, R.
Revista Medica de Chile 120(2): 168-173
1992
ISSN/ISBN: 0034-9887 PMID: 1340555 Document Number: 391631
Bromocriptine was used to treat 3 patients with prolactin secreting pituitary adenoma. Diagnosis was based on the presence of a sellar tumor over 1 cm in size at CT scanning and a serum prolactin concentration above 150 ng/ml. All patients were symptomatic from pituitary hypofunction or from tumor compression of neighboring areas. Bromocriptine was given at increasing doses up to 10 mg/day. Prolactin reached normal levels 1 to 7 months later, tumor reduction was confirmed by high resolution scanning. The mechanism of bromocriptine effect on these tumors is discussed.