Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice
Leiter, E.H.; Serreze, D.V.
Regional Immunology 4(5): 263-273
1992
ISSN/ISBN: 0896-0623 PMID: 1290746 Document Number: 391451
Genetically-controlled defects in the development and function of antigen presenting cells may explain why NOD mice exhibit an impaired ability to induce tolerance and/or activate immunoregulatory T cells. These defects provide understanding for why diabetogenesis in NOD mice is so sensitive to immunomodulatory changes mediated through the environment. Although the unique MHC haplotype of NOD mice is clearly a major contributor to diabetes susceptibility, evidence for a complex interaction between MHC loci and many other polygenetic factors is reviewed.