The prognostic significance of changes in the level of natural antibodies to thrombin in stenocardia patients
Gavrilov, O.K.; Novozhenova, T.V.; Lekokhmakher, S.S.; Dobashina, A.N.; Fedoseev, A.N.; Miagkova, M.A.
Klinicheskaia Meditsina 70(1): 23-26
1992
ISSN/ISBN: 0023-2149 PMID: 1608202 Document Number: 390835
Coagulation in angina pectoris has been analyzed in a normal and elevated level of natural antibodies (nAb) to thrombin. A correlation was found between the level of nAb to thrombin and hemostatic shifts. The correlation of a nAb rise was attempted by means of plasmapheresis (PA) or plasmosorption (PS), altering coagulation potential. PA and PS produced more pronounced anticoagulative effects in patients with a normal baseline level of nAb to thrombin. When the latter levels tended to reduction from initially high, hemostatic processes improved. It is concluded that nAb to thrombin levels have prognostic potential as an indicator of coagulation activity and efficacy of anticoagulant therapy in extracorporeal interventions.