Understanding the significance of low-level preformed donor-specific anti-HLA antibodies in renal transplant patients
Wu, P.; Everly, M.J.; Jin, J.; Mao, Y.; Chen, J.
Clinical Transplants 2011: 365-368
2011
ISSN/ISBN: 0890-9016 PMID: 22755432 Document Number: 649880
This is a single center, retrospective cohort study showing the impact of pre-transplant HLA-DSA (detected by the SAFB) on early posttransplant rejection rates. Our results showed that low level pretransplant DSA detected by SAFB is associated with a high risk of early clinical AMR. However, not all patients with pretransplant DSA will go on to develop AMR. Post-transplant with a decrease/removal of DSA within one month will lead to a low rate of AMR. Conversely, those who have a high DSA MFI are at the highest risk of early AMR. These findings support using SAFB for pretransplant assessment and early posttransplant monitoring.