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Aztreonam versus colistin-neomycin for selective decontamination of the digestive tract in patients undergoing bone marrow transplantation: a randomized study

Bosi, A.; Fanci, R.; Pecile, P.; Guidi, S.; Saccardi, R.; Vannucchi, A.M.; Longo, G.; Donnini, E.; Orsi, A.; Rossi-Ferrini, P.

Journal of Chemotherapy 4(1): 30-34

1992

ISSN/ISBN: 1120-009X
PMID: 1403068
Document Number: 390041
Aztreonam (Az), a minimally absorbable monobactam antibiotic, was compared to colistin plus neomycin (CN), for intestinal decontamination during Bone Marrow Transplantation (BMT) in a controlled study. Thirty-four consecutive patients were randomized in two groups and evaluated for number of febrile episodes, day of fever, fecal cultures and clinical symptoms related to infections or colonications. No significant differences were observed suggesting that Az is at least as effective as the CN regimen and may be considered as an alternative approach for intestinal decontamination in BMT patients.

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