Pregnancy in renal transplant recipients. Long-term evaluation of their children
García, R.; Henríquez, C.; Herrera, J.; Salgado, O.; Rincón-Tudares, E.; Rodríguez-Iturbe, B.
Investigacion Clinica 33(2): 55-60
1992
ISSN/ISBN: 0535-5133 PMID: 1457532 Document Number: 390021
The course of eight pregnancies in seven renal transplant patients was analyzed. Immunosuppression consisted of Azathioprine and Prednisone. Pregnancy lasted from 32 to 39 weeks and the fetal development corresponded to the gestational age in every case. There were three cases which had complications during the pregnancy. One case had severe arterial hypertension, proteinuria and pedal edema, which was thought to be due to pre-eclampsia. Another patient had cholestatic jaundice and premature fissure of membranes and the third patient also had this last complication. Four patients had vaginal deliveries and in four cesarean section was performed. Renal function did not deteriorate during any of the pregnancies nor during the follow-up period, but the expected increase in creatinine clearance was not found. Clinical evaluation of the children, 4 months to 8 years of age, did not disclose any abnormalities.