The mechanism of the effect of reserpine on endocrine system function
Ablaev, N.R.; Pichkhadze, G.M.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(4): 33-35
1992
ISSN/ISBN: 0869-2092 PMID: 1333866 Document Number: 389745
The experiments in rabbits and guinea-pigs showed that the use of reserpine, 0.1 and 0.25 mg/kg body weight a day, led to a 2-2.8-fold increase in thyroid hormones and 25-45% enhancement in cortisol in the blood. At the same time cAMP concentrations increased by 87% and almost by 5 times in the thyroid and adrenals, respectively. The pancreas exhibited a 5-fold increase in cAMP, 2.5- and 2.3-fold decrease in insulin in rabbit peripheral blood and in the activity of pancreatic aldolase and dehydrogenases, respectively. Blood levels of glucose reduced by 15-17%.