Composite lymphoma in Sjogren's syndrome with mixed cryoglobulinemia
Shpilberg, O.; Zinger, R.; Horowitz, A.; Langevitz, P.
Harefuah 123(5-6): 157-159; 236
1992
ISSN/ISBN: 0017-7768 PMID: 1427471 Document Number: 389740
A 44-year-old woman with Sjogren's syndrome and mixed cryoglobulinemia developed nodal and pulmonary lymphoma 15 years after the initial diagnosis. The nodal lymphoma was of the composite type and included both monoclonal monocytoid and lymphoplasmacytoid B-cells. The extranodal pulmonary lymphoma included only lymphoplasmacytoid lymphocytes. Complete resolution of the lymphoma was achieved following 3 months of chlorambucil, 5 mg/day, and prednisone, 30 mg/day. Composite lymphoma and monocytoid lymphoma are being encountered more commonly among patients with Sjogren's syndrome. Physicians must therefore become more aware of the existence of both entities.