Studies on variations of glycoproteins and lysosomal hydrolases in human uterine cervical carcinoma
Bhuvarahamurthy, V.; Balasubramanian, N.; Subramanian, S.; Govindasamy, S.
Biochemistry International 28(1): 105-111
1992
ISSN/ISBN: 0158-5231 PMID: 1445383 Document Number: 388653
Variations of glycoprotein components such as hexose, hexosamine, and sialic acid and lysosomal glycosidases such as beta-D-glucosidase, beta-D-galactosidase, and N-acetyl-beta-D-glucosaminidase were studied in the tumor tissue from various stages of cervical carcinoma of the uterus. Carbohydrate components of glycoprotein were found to be markedly reduced, and the reduction was very much significant in hexosamine and sialic acid in the advanced stages. Lysosomal glycosidases exhibited a significant increase, and among them N-acetyl-beta-D-glucosaminidase exhibited a prominent increase, in the advanced stages of cervical carcinoma of the uterus.