Clinical manifestations of Lyme disease in the United States
Trock, D.H.; Craft, J.E.; Rahn, D.W.
Connecticut Medicine 53(6): 327-330
1989
ISSN/ISBN: 0010-6178 PMID: 2667885 Document Number: 3886
In summary, Lyme disease usually begins during the summer months with erythema migrans and flu-like symptoms, followed weeks to months later by cardiac or neurologic complications in a minority of affected individuals. Arthritis occurs in many untreated patients weeks to years after disease onset. Early antibiotic therapy generally aborts the later manifestations of Lyme disease and aggressive antibiotic therapy is generally effective in eradication of infection during later stages of illness. Current clinical research efforts are being directed toward prevention of infection, improvement in methods of serologic diagnosis, further delineation of the clinical spectrum, and optimizing treatment of all stages of disease.
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