Clinical effectiveness and potential hazards of combined kordaron and quinidine therapy of patients with atrial fibrillation
Lipnitskiĭ, T.N.; Dorogan, A.V.; Randin, A.G.; Kotsuta, G.I.
Klinicheskaia Meditsina 70(3-4): 31-34
1992
ISSN/ISBN: 0023-2149 PMID: 1507842 Document Number: 388243
Clinical efficacy of and potential risk for complications from combined cordarone+quinidine treatment were studied in 52 patients with atrial fibrillation (AF). Out of 32 patients with a persistent pattern of the disease the sinus rhythm was recovered in 28 (87.5%) of the patients; out of 20 patients with paroxysmal pattern of AF resistant to routine anti-arrhythmic treatment, the sinus rhythm was recovered in 14 (70%) patients. Almost 50% Q-T prolongation was recorded in one patient with paroxysmal AF. Despite the withdrawal of the medication, 4 hours later ventricular tachycardia of the "pirouette" type arose that 2-3 minutes later was followed by ventricular fibrillation with clinical death. After effective electric defibrillation in the presence of lidocaine treatment ventricular fibrillation repeated 7 times. A total of 32 cardiac defibrillations were performed for 6 hours. The normalization of the Q-T interval was observed on the fourth day only. The patient was discharged from the hospital in a satisfactory condition.