High dose chemotherapy with autologous bone marrow transplantation and G-CSF for hematologic malignancies
Takeyama, K.; Tobinai, K.; Shimoyama, M.
Nihon Rinsho. Japanese Journal of Clinical Medicine 50(6): 1414-1418
1992
ISSN/ISBN: 0047-1852 PMID: 1381452 Document Number: 388154
High dose chemotherapy (HDCT) followed by autologous bone marrow transplantation (ABMT) is one of the cure-oriented therapies for hematologic malignancies. Colony stimulating factors (CSFs) are currently used to stimulate hematopoiesis in various cytopenic conditions including post BMT. Granulocyte CSF (G-CSF) significantly accelerates granulocyte recovery after ABMT. Earlier recovery of neutrophils is associated with lower incidence of severe infections and shorter duration of reverse barrier nursing and hospitalization. Widespread use of G-CSF in ABMT may contribute to managing this treatment safely in multi-centers. Further prospective clinical study to define the optimal application and timing of HDCT with ABMT in hematologic malignancies is required.