Experimental study of the treatment of carcinomatous peritonitis in gastric cancer
Kitamura, M.; Arai, K.; Miyashita, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 19(10 Suppl): 1720-1723
1992
ISSN/ISBN: 0385-0684 PMID: 1530340 Document Number: 387960
To prevent dissemination to the peritoneum following surgery for gastric cancer, examinations were performed with mouse ascites cancer models and the objective of enhancing the combined effect of MMC, CDDP and 5-FU. Pharmaceutical dosage was set at approximately 30% of the increased life span (ILS) for Meth-A. The dosage was 0.2 mg/kg for MMC, 1 mg/kg for CDDP and 37.5 mg/kg for 5-FU. Results indicated that simultaneous combination of 0.2 mg/kg of MMC and 1 mg/kg of CDDP extended life significantly more than individual administration, and clinical application of this combination was considered to be possible. In contrast, simultaneous combination of 1 mg/kg of CDDP and 37.5 mg/kg of 5-FU had no clear life-extending effect compared to individual administration of each. Some biochemical modulation of the administration method was thus considered necessary.