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Studies on antiaggregating drugs of horseshoe crab amebocytes

Chen, I.J.; Hwang, S.J.; Chen, Y.M.

Gaoxiong Yi Xue Ke Xue Za Zhi 7(7): 376-381

1991

ISSN/ISBN: 0257-5655
PMID: 1652032
Document Number: 387670
The effects of drugs on amebocyte spontaneous aggregation and endotoxin induced aggregation were studied. N-Ethylmaleimide, ethylenediamine tetraacetate, propranolol, verapamil and lidocaine but not dibutyryl cyclic AMP could reduce the aggregating rate of amebocytes. The speed of degranulation induced by endotoxin was reduced by N-ethylmaleimide, ethylenediamine tetraacetate, propranolol, verapamil and caffeine. These results suggest that Ca+2 and c-AMP may play an important role in amebocyte spontaneous aggregation and endotoxin induced aggregation. The blocking agents of Ca+2 and c-AMP can also antagonize the aggregation of amebocytes.

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