Cycloocta[b]pyran derivatives with local anesthetic, platelet antiaggregating and other activities
Longobardi, M.; Bargagna, A.; Mariani, E.; Schenone, P.; D'Amico, M.; Falciani, M.; Filippelli, W.; Contaldi, C.
Farmaco 50(1): 55-59
1995
ISSN/ISBN: 0014-827X PMID: 7702722 Document Number: 450758
The synthesis of some N,N-disubstituted 4-amino-5,6,7,8,9,10-hexahydro-3- phenyl-2H-cyclooctapyran-2-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 2-aminomethylenecyclooctanones, followed by dehydrochlorination in situ of the primary adducts with DBN, is described. The dimethylamino derivative showed a local anesthetic activity in mice superior to that of lidocaine, and some compounds exhibited a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as weak antiarrhythmic and antiinflammatory activities in rats.