Rhino-cerebral mucormycosis and hematological neoplasia
Pintado, V.; Valencia, M.E.; López-Dupla, J.M.; Lavilla, P.; Feliú, J.; Gil, A.
Sangre 36(2): 141-143
1991
ISSN/ISBN: 0036-4355 PMID: 1866653 Document Number: 387214
Mucormycosis is a rare infection that occurs in immunocompromised patients. The rhinocerebral form presents in diabetics as a severe necrotizing sinusitis and is not frequent in patients with haematologic malignancies. Diagnosis requires direct examination and culture of biopsy specimens. Two patients with rhinocerebral mucormycosis and haematologic neoplasms (Non-Hodgkin's lymphoma and acute myeloblastic leukaemia) are described. Both patients had severe drug-induced neutropenia when the infection appeared. One patient died in spite of aggressive treatment with surgery and amphotericin.