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Interactions between human and porcine interferons

Filipic, B.; Golob, A.; Tóth, S.; Mécs, I.; Béládi, I.; Likar, M.

Acta Virologica 35(1): 19-26

1991

ISSN/ISBN: 0001-723X
PMID: 1719784
Document Number: 387098
To investigate the possible interactions between human and porcine interferons (IFNs) in vitro, human transformed (FL) and nontransformed (HEF) cells were treated with either HuIFN alpha and/or gamma and porcine alpha and/or gamma. In both cases the antiproliferative activity was measured to determine the effects of different combinations between human and porcine IFNs on cell proliferation. Combinations of human and porcine IFNs acted mostly antagonistically with exception of IFN combination Hu-alpha/Po-gamma which showed a synergic cooperativity in therms of antiproliferative activity on human transformed cells.

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