Intradermal antityphoid-antitetanus vaccination by jet injection
Dimache, G.; Croitoru, M.; Velea, V.; Stoean, C.; Durbacă, S.; Mihăilescu, M.; Dimache, A.
Roumanian Archives of Microbiology and Immunology 50(2): 127-135
1991
ISSN/ISBN: 1222-3891 PMID: 1820189 Document Number: 386928
A lyophilized, heat-killed, phenol preserved typhoid vaccine (5 x 10(8) cells) suspended in 0.1 ml unadsorbed concentrated tetanus vaccine (10 Lf) was administered in man by intradermal route. This association of the two vaccines resulted in milder postvaccinal reactions: moreover, the immunological properties of typhoid vaccine, as certified by the passive protection test of the mouse with sera of the vaccines and the H and O agglutinin titres found in these immune sera, were perfectly conserved. Consequently, the mixed typhoid-tetanus vaccination in man by intradermal route is possible and advantageous for practical and economical reasons.