Differential diagnosis of kidney transplant rejection and ciclosporin nephrotoxicity by urine cytology
Kyo, M.; Mihatsch, M.J.
Hinyokika Kiyo. Acta Urologica Japonica 37(10): 1153-1158
1991
ISSN/ISBN: 0018-1994 PMID: 1721768 Document Number: 386777
To make the differentiation of kidney transplant acute rejection and ciclosporin (CS) nephrotoxicity urine cytology by classical Papanicolaou with immunocytochemical strain has been performed. Increased numbers of renal tubular cells with lymphocytes and monocytes were found in born rejections and CS toxicites. CS toxicities were associated with increased numbers of proximal tubular cells. In immunocytochemical stain, increased numbers of CD25 and CD8 positive cells as well as increased ratio of HLA-DR/cytokeratin positive cells were typically found in rejections. It is concluded that the proposed analysis of urine cytology is a non-invasive and reliable method for daily graft monitoring of acute rejection and CS toxicity.